Tsutomu Ogata Selected Research

Aromatase (CYP19)

7/2014	Understanding the pathological manifestations of aromatase excess syndrome: lessons for clinical diagnosis.
5/2014	Lack of genomic rearrangements involving the aromatase gene CYP19A1 in breast cancer.
3/2014	Aromatase excess syndrome: a rare autosomal dominant disorder leading to pre- or peri-pubertal onset gynecomastia.

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Tsutomu Ogata Research Topics

Disease

10	Neoplasms (Cancer) 01/2021 - 01/2008
10	Hypospadias 02/2018 - 12/2006
9	Penis agenesis 11/2023 - 01/2002
9	Antley-Bixler Syndrome Phenotype 01/2018 - 01/2005
7	Cryptorchidism (Undescended Testes) 02/2018 - 08/2005
6	Pseudohypoparathyroidism 01/2024 - 01/2013
6	Hypogonadism (Hypergonadotropic Hypogonadism) 01/2022 - 06/2004
6	Noonan Syndrome (Female Pseudo-Turner Syndrome) 08/2020 - 08/2002
6	Type 1 Diabetes Mellitus (Autoimmune Diabetes) 01/2018 - 02/2012
5	Combined Pituitary Hormone Deficiency 01/2022 - 02/2010
5	Gynecomastia 01/2021 - 06/2011
5	Azoospermia 01/2018 - 12/2002
5	Congenital adrenal hyperplasia due to 21 hydroxylase deficiency 04/2016 - 02/2006
4	Inborn Genetic Diseases (Disease, Hereditary) 07/2023 - 01/2012
3	Diabetes Mellitus 01/2024 - 01/2010
3	Intellectual Disability (Idiocy) 12/2023 - 01/2015
3	Prader-Willi Syndrome (Syndrome, Prader-Willi) 05/2023 - 06/2012
3	Congenital, Hereditary, and Neonatal Diseases and Abnormalities (Congenital Disorders) 10/2022 - 10/2021
3	Imprinting Disorders 10/2022 - 01/2016
3	Polycystic Ovary Syndrome (Syndrome, Stein-Leventhal) 10/2018 - 01/2016
3	Hyperphosphatemia 01/2018 - 01/2013
3	Virilism (Virilization) 01/2018 - 05/2009
3	Precocious Puberty 12/2017 - 01/2015
3	Leri-Weil syndrome 07/2016 - 12/2002
3	Kallmann Syndrome (Kallmann's Syndrome) 04/2006 - 03/2004
2	Insulin Resistance 01/2024 - 03/2005
2	Disorders of Sex Development (Intersexuality) 11/2023 - 05/2009
2	Hypocalcemia 10/2022 - 01/2013
2	Hypoglycemia (Reactive Hypoglycemia) 01/2021 - 09/2017
2	Hypophosphatasia 01/2020 - 07/2017
2	Megalencephaly 01/2020 - 05/2014
2	XX Disorders of Sex Development 46 (Female Pseudohermaphroditism) 01/2019 - 05/2009
2	Hypersensitivity (Allergy) 01/2018 - 01/2009
2	Hypercalcemia (Milk Alkali Syndrome) 01/2018 - 12/2013
2	Silver-Russell Syndrome 12/2017 - 08/2012
2	Congenital Adrenal Hyperplasia (Hyperplasia, Congenital Adrenal) 10/2016 - 01/2014
2	Beckwith-Wiedemann Syndrome (Exomphalos Macroglossia Gigantism Syndrome) 12/2014 - 08/2012
2	Uniparental Disomy 04/2014 - 01/2014
2	Renal hypouricemia 03/2014 - 07/2004
2	46,XY Disorder of Sex Development (Male Pseudohermaphroditism) 10/2012 - 05/2009
2	Pituitary Dwarfism 02/2011 - 02/2010
2	LEOPARD Syndrome (Syndrome, LEOPARD) 10/2010 - 06/2005
2	Anophthalmos (Anophthalmia) 10/2008 - 02/2007

Drug/Important Bio-Agent (IBA)

12	SteroidsIBA 11/2023 - 12/2004
9	Testosterone (Sustanon)FDA Link 11/2023 - 12/2004
8	DNA (Deoxyribonucleic Acid)IBA 05/2023 - 01/2002
8	Estrogens (Estrogen)FDA Link 01/2022 - 03/2002
7	Insulin (Novolin)FDA Link 01/2024 - 03/2005
7	Oxidoreductases (Dehydrogenase)IBA 11/2023 - 01/2005
7	Proteins (Proteins, Gene)FDA Link 01/2021 - 01/2002
7	Hormones (Hormone)IBA 01/2018 - 06/2004
6	Type 1 Fibroblast Growth Factor Receptor (Fibroblast Growth Factor Receptor 1)IBA 01/2022 - 03/2004
6	AndrogensIBA 10/2018 - 04/2016
5	RNA Splice SitesIBA 01/2024 - 01/2012
5	due to increased aromatase activity familial gynecomastiaIBA 01/2021 - 06/2011
5	AutoantibodiesIBA 01/2018 - 01/2010
5	EnzymesIBA 05/2014 - 07/2003
4	Growth Hormone (Somatotropin)IBA 05/2023 - 10/2008
4	Phosphates (Orthophosphate)IBA 01/2020 - 01/2013
4	GonadotropinsIBA 12/2017 - 12/2004
4	Cytochrome P-450 Enzyme System (Cytochrome P450)IBA 12/2014 - 01/2005
3	Glucose (Dextrose)FDA LinkGeneric 01/2024 - 03/2005
3	Transcription Factors (Transcription Factor)IBA 01/2020 - 08/2010
3	CalciumIBA 01/2020 - 12/2013
3	Follicle Stimulating Hormone (Follitropin)FDA Link 01/2018 - 06/2004
3	Androgen Receptors (Androgen Receptor)IBA 01/2018 - 07/2004
3	Steroid 21-Hydroxylase (21 Hydroxylase)IBA 10/2016 - 10/2013
3	GlucocorticoidsIBA 10/2016 - 10/2013
3	Gonadotropin-Releasing Hormone (GnRH)FDA Link 09/2016 - 12/2004
3	Hydrocortisone (Cortisol)FDA LinkGeneric 04/2016 - 12/2004
3	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2015 - 01/2007
3	hydrogen sulfite (bisulfite)IBA 12/2014 - 08/2012
3	Aromatase (CYP19)IBA 07/2014 - 03/2014
3	Nonsense Codon (Nonsense Mutation)IBA 01/2009 - 12/2006
3	Estrogen Receptor alphaIBA 05/2007 - 12/2002
3	Protein Tyrosine PhosphatasesIBA 06/2005 - 08/2002
3	Aryl Hydrocarbon Receptors (Aryl Hydrocarbon Receptor)IBA 02/2005 - 01/2002
2	Mixed Function Oxygenases (Monooxygenases)IBA 04/2024 - 10/2013
2	Steroid 17-alpha-Hydroxylase (17 alpha Hydroxylase)IBA 04/2024 - 10/2013
2	Chorionic Gonadotropin (Human Chorionic Gonadotropin)FDA LinkGeneric 11/2023 - 01/2015
2	RNA (Ribonucleic Acid)IBA 07/2023 - 07/2022
2	N-Acetylneuraminic Acid (Sialic Acid)IBA 10/2022 - 01/2014
2	Parathyroid Hormone (Parathormone)IBA 10/2022 - 01/2018
2	SilverIBA 10/2022 - 01/2016
2	Human Growth Hormone (Saizen)FDA LinkGeneric 08/2020 - 02/2018
2	Alkaline PhosphataseIBA 01/2020 - 07/2017
2	asfotase alfaIBA 01/2020 - 07/2017
2	Cytochrome P-450 CYP1A1 (CYP1A1)IBA 02/2018 - 07/2012
2	Dihydrotestosterone (Androstanolone)IBA 01/2018 - 07/2006
2	GTP-Binding Proteins (G-Protein)IBA 01/2018 - 01/2016
2	Glutamate Decarboxylase (Decarboxylase, Glutamate)IBA 09/2016 - 01/2010
2	pregnanetrioloneIBA 04/2016 - 04/2012
2	Adrenocorticotropic Hormone (ACTH)FDA Link 01/2015 - 12/2004
2	CreatinineIBA 12/2013 - 06/2004
2	Steroidogenic Factor 1IBA 10/2012 - 01/2009
2	bisphenol AIBA 01/2012 - 01/2012
2	Aromatase deficiencyIBA 05/2009 - 02/2006
2	Biotin (Vitamin H)FDA Link 01/2009 - 06/2008

Therapy/Procedure

9	Therapeutics 05/2023 - 07/2002
3	Ligation 01/2016 - 01/2013